Archive for the 'investigaciones'

Miércoles 22 / enero / 2014

Effects of antihypertensive drugs on central blood pressure: new evidence, more challenges

Filed under: investigaciones — Mario Hernández Cueto — enero 22nd, 2014 — 8:35

Effects of antihypertensive drugs on central blood pressure: new evidence, more challenges

InvestigacionesPor: Giacomo Pucci, Francesca Battista y Giuseppe Schillaci.  Hypertension Research (2014) 37, 10–12.

βa-blocking drugs have long been used as a first-line therapy for hypertension because of their well-established efficacy in lowering brachial blood pressure (BP) and their long-term favorable effects on all-cause and cardiovascular mortality, as shown in a number of prospective large-scale trials and meta-analyses.  More recently, their use as a preferred strategy for the treatment of essential hypertension has been challenged, as their protective effect on incident stroke may be suboptimal.

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Jueves 9 / enero / 2014

How can resistant hypertension be identified and prevented?

Filed under: investigaciones — Mario Hernández Cueto — enero 9th, 2014 — 8:34

How can resistant hypertension be identified and prevented?

InvestigacionesPor: Anna Solini y Luis M. Ruilope. (ruilope@ad-hocbox.comNature Reviews Cardiology 10, 293-296 (May 2013).

Resistant hypertension is highly prevalent, and is the form of arterial hypertension that is most difficult to treat. Many patients diagnosed with this disease do not have resistant hypertension, but rather have mismanaged primary hypertension. In many cases blood pressure can be controlled by directly addressing underlying causes such as primary aldosteronism, obstructive sleep apnoea, or excessive neurogenic stimulation. Clinicians should ensure that appropriate blood-pressure measurements are used to diagnose resistant hypertension, explore a variety of drug combinations, and battle clinical inertia. Patients should comply with medication schedules and dietary modifications.

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Viernes 6 / diciembre / 2013

Assessment and management of blood-pressure variability

Filed under: investigaciones — Mario Hernández Cueto — diciembre 6th, 2013 — 8:29

Assessment and management of blood-pressure variability

InvestigacionesPor: Gianfranco Parati, Juan E. Ochoa, Carolina Lombardi y Grzegorz Bilo.  Nature Reviews Cardiology 10, 143-155 (March 2013).

Blood pressure (BP) is characterized by marked short-term fluctuations occurring within a 24 h period, including beat-to-beat, minute-to-minute, hour-to-hour, and day-to-night changes. Long-term, substantial variations in BP have also been shown to occur over more-prolonged periods of time, for example days, weeks, months, seasons, and even years. Rather than representing ‘background noise’, or a phenomenon occurring at random, these variations are thought to be the result of complex interactions between extrinsic environmental and behavioural factors and intrinsic cardiovascular regulatory mechanisms (neural central, neural reflex, and humoral influences) that are not yet completely understood.

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Jueves 21 / noviembre / 2013

Interpreting treatment-induced blood pressure reductions measured by ambulatory blood pressure monitoring

Filed under: investigaciones — Mario Hernández Cueto — noviembre 21st, 2013 — 9:13

Interpreting treatment-induced blood pressure reductions measured by ambulatory blood pressure monitoring

Por: R E Schmieder, L M Ruilope, C Ott1, F Mahfoud y M Böhm.  Journal of Human Hypertension (2013) 27, 715–720, May 2013.

InvestigacionesIt is well known that 24-h ambulatory blood pressure monitoring (ABPM) provides a more accurate picture of a patient’s blood pressure (BP) compared with clinic BP measurement. Twenty-four-hour ABPM better predicts hypertension-related risks such as end-organ damage including left ventricular hypertrophy, cardiovascular (CV) events and mortality. Threshold BP values for hypertension based on 24-h ABPM results have been established, including daytime and night-time averages. Nevertheless, the relationship between 24-h ABPM and clinic BP measurement in patients on antihypertensive therapy, and in particular how each may change in response to antihypertensive therapy, is less clear.

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