Blood pressure control and favourable pleiotropic effects of aliskiren

Posted at — Mario Hernández Cueto — febrero 8th, 2013 — 8:19 under comentario

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Blood pressure control and favourable pleiotropic effects of aliskiren

ComentandoPor: Graziano Riccioni.  Hypertension Research (2013) 36, 102–103.

Hypertension and its acute and chronic complications are one of the most important risk factors associated with significant morbidity and mortality worldwide and will increase in importance as a public health problem by 2020.1 The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC7) establishes that the goal of antihypertensive therapy is to reduce cardiovascular and renal morbidity and mortality. Despite the wide range of antihypertensive agents available, less than one third of patients with hypertension have their blood pressure (BP) controlled. The mechanism of primary (essential) hypertension includes genetic predisposition, endothelial cell dysfunction, sympathetic nervous system (SNS) hyperactivity, abnormalities in renin angiotensin aldosterone system (RAAS) function, hyperinsulinism and insulin resistance. [Actualizado: 8 de febrero de 2013]

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