Archive for the 'nejm'

Jueves 22 / noviembre / 2012

Mechanisms of Disease: Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases

Filed under: nejm — José Pedro Martínez — noviembre 22nd, 2012 — 6:59 AM

New England Journal of Medicine
Mechanisms of Disease: Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases

nejmIn an era in which new biologics are being introduced to target inflammation and autoimmunity, some older treatments persist. Immune globulin–replacement therapy has been a lifesaving treatment for patients with antibody deficiency. When immune globulin replacement was introduced in the 1950s for the treatment of primary immunodeficiency diseases, it was administered subcutaneously or by intramuscular injection; subsequently, preparations suitable for intravenous use were developed, and these have undergone progressive changes in composition, particularly the elimination of sugars and normalization of the salt content and osmolarity. As a result, reactions have become much less frequent.

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Viernes 16 / noviembre / 2012

Differentiation of Reinfection from Relapse in Recurrent Lyme Disease_NEJM

Filed under: nejm — José Pedro Martínez — noviembre 16th, 2012 — 10:33 PM

Differentiation of Reinfection from Relapse in Recurrent Lyme Disease

enfermedad de LymeThe New England Journal of Medicine

Erythema migrans is the most common manifestation of Lyme disease. Recurrences are not uncommon, and although they are usually attributed to reinfection rather than relapse of the original infection, this remains somewhat controversial. We used molecular typing of Borrelia burgdorferi isolates obtained from patients with culture-confirmed episodes of erythema migrans to distinguish between relapse and reinfection.

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Viernes 16 / noviembre / 2012

The Most Important Article in NEJM History

Filed under: nejm — José Pedro Martínez — noviembre 16th, 2012 — 2:26 PM

The Most Important Article in NEJM History

The New England Journal of Medicine

Insensibility during Surgical Operations Produced by Inhalation
Insensibility during Surgical Operations Produced by Inhalation

Throughout the 200th anniversary year we have asked for your votes, and you have responded with a resounding favorite. Since the 1846 report from Boston surgeon Henry Jacob Bigelow, “Insensibility during Surgical Operations Produced by Inhalation,” so many of the significant advances we’ve seen rely on the use of anesthesia. It is difficult to imagine medicine today without it. If you haven’t read the original report yet, it’s worth taking a few minutes to travel back to the mid-nineteenth century, when Bigelow wrote, “It has long been an important problem in medical science to devise some method of mitigating the pain of surgical operations.” The beginning of ether anesthesia won the final round of voting against many other significant developments published in NEJM over the last two centuries: the first description of platelets, the beginning of bone marrow transplantation, studies on an attenuated measles vaccine, the first oral ACE inhibitor, the knowledge that aspirin prevents heart attacks, the first treatment of stroke, or understanding how to prevent type II diabetes. Explore the historical timeline for more milestones.

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