Instituto de Hematología e Inmunología

20 mayo 2016

Esta semana en BLOOD; no te lo pierdas!

Filed under: Novedades — ihi @ 9:16
This Week in Blood
Volume 127, Issue 20

Complete Table of Contents


Cover Figure: Review series: 2016 revision of the WHO classification of myeloid and lymphoid neoplasms. See the article by Swerdlow et al.

WASHINGTON, May 19,  2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
The most recent World Health Organization classification of Tumours of Haematopoietic and Lymphoid Tissues was published in 2008. The intervening 8 years have seen an explosion of new genetic information about hematopoietic neoplasms that remain to be integrated into diagnostic algorithms for these diseases. Swerdlow and colleagues and Arber and colleagues summarize the revision to the prior classification that incorporates new clinical, prognostic, morphologic, immunophenotypic, and genetic data.

Phase 2 study of idelalisib and entospletinib: pneumonitis limits combination therapy in relapsed refractory CLL and NHL
Barr and colleagues report the outcome of a phase 2 study of the combination of the phosphatidylinositol 3-kinase δ inhibitor idelalisib and the spleen tyrosine kinase inhibitor entospletinib for the treatment of refractory chronic lymphocytic leukemia and non-Hodgkin lymphoma. Although patients had significant responses, the study was terminated early because of treatment-related pneumonitis occurring in 18% of patients with 2 deaths.

Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis
Teira and colleagues report a retrospective analysis of the impact of cytomegalovirus (CMV) reactivation on relapse and survival in over 9000 recipients of hematopoietic stem cell transplants. Despite current better treatment regimens directed at the virus, CMV reactivation remains a risk factor for transplant-related mortality. Furthermore, in contrast to some previous studies, CMV is not associated with decreased leukemia relapse.

Rapid discrimination of the phenotypic variants of von Willebrand disease

Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States
The diagnosis of VWD subtypes remains somewhat challenging, as highlighted in two articles in this week’s issue. In this month’s CME article, Roberts and colleagues report on the development of an enzyme-linked immunosorbent assay–based assay that accurately diagnoses phenotypic subsets of von Willebrand disease (VWD) with over 85-95% accuracy. This rapid test may streamline the appropriate diagnosis of patients with VWD variants. In a second article, Flood and colleagues examine the correlations among the bleeding assessment tool, von Willebrand factor (VWF) levels, and detectable mutations in VWF genes in 482 individuals carrying a diagnosis of type 1 VWD. They report that VWF levels do not predict for bleeding scores, but low VWF levels predict for sequence variants in the VWF gene.

Comprehensive mutational profiling of core binding factor acute myeloid leukemia

RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
Two publications expand our understanding of the genetics of core binding factor acute myeloid leukemia (AML). In the first, Duployez and colleagues performed deep sequencing of 40 known myeloid malignancy–associated genes in over 200 patients with t(8;21) and inv(16) AML, demonstrating that the patterns of mutations in the 2 subtypes are different and pinpointing mutations predictive of poor prognosis in t(8;21). In a letter to Blood, Lavallée and colleagues describe an untargeted RNA-sequencing analysis of 48 samples, identifying novel mutations that could not be predicted by the targeted sequencing approach.

This week’s complete table of contents

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The Lancet último número: Vol.387 | Number 10033 | May 21, 2016

Filed under: Novedades — ihi @ 9:13


No health workforce, no global health security


Learning Together to improve children’s health

The Lancet

No ifs, no buts, no follow-on milk

 The Lancet


Does paracetamol still have a future in osteoarthritis?

Nicholas Moore, Francesco Salvo, Mai Duong, Sinem Ezgi Gulmez

Progestogens and preterm birth—not the hoped for panacea?

Ben W J Mol, Mandy Daly, Jodie M Dodd

Open Access

Tocolysis and preterm labour

Kate F Walker, Jim G Thornton

Microcephaly and Zika virus infection

Laura C Rodrigues

Late maternal deaths: a neglected responsibility

Karen Sliwa, John Anthony

Six ways for governments to get value from health IT

Kathrin Cresswell, David W Bates, Aziz Sheikh

Respiratory medicine: a call for papers

Emma Grainger, Sabine Kleinert

Offline: India—a great nation, marred

Richard Horton

World Report

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Doubts over India’s deadline to defeat lymphatic filariasis

Sophie Cousins

Helping Colombia’s landmine survivors

Joe Parkin Daniels


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Yasuhisa Shiozaki: Japan’s progressive Minister of Health

Richard Lane
Case histories


Richard Barnett


Stephen Ginn
The art of medicine

Utopia, health, and happiness

Phil Withington

A modern Prometheus

Pam Hodge

Voices in global health: present realities, future challenges

James Smith


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Thomas Herald Rea

Geoff Watts


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Breastfeeding in the 21st century

Dylan Walters, Jakub Jan Kakietek, Julia Dayton Eberwein, Thomas Pullum, Meera Shekar

Breastfeeding in the 21st century

John Wallingford

Breastfeeding in the 21st century

Maria A Quigley, Claire Carson

Breastfeeding in the 21st century

Marilyn Agranonik, André Krumel Portella, Jill Hamilton, Alison S Fleming, Meir Steiner, Michael J Meaney, Robert D Levitan, Patrícia Pelufo Silveira, MAVAN study team

Breastfeeding in the 21st century

Mary J Renfrew

Breastfeeding in the 21st century – Authors’ reply

Cesar G Victora, Nigel C Rollins, Simon Murch, Julia Krasevec, Rajiv Bahl

Trial size, HIV pre-exposure prophylaxis, and breastfeeding

Sheila M Bird

Trial size, HIV pre-exposure prophylaxis, and breastfeeding – Authors’ reply

Carl Lombard, Simon Cousens, Thorkild Tylleskär, Philippe Van de Perre, Nicolas Nagot

Decoding vital signs during triage: pulse pressure in children

Frederick M Burkle, James A Geiling

Decoding vital signs during triage: pulse pressure in children – Author’s reply

Trevor Duke

Lung, e-cigarettes, and health: response from the Royal College of Physicians

Jane Dacre, John Britton

Department of Error

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Department of Error


Department of Error



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Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle

Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial

Jane Elizabeth Norman, Neil Marlow, Claudia-Martina Messow, Andrew Shennan, Phillip R Bennett, Steven Thornton, Stephen C Robson, Alex McConnachie, Stavros Petrou, Neil J Sebire, Tina Lavender, Sonia Whyte, John Norrie, OPPTIMUM study group

Open Access

Nifedipine versus atosiban for threatened preterm birth (APOSTEL III): a multicentre, randomised controlled trial

Elvira O G van Vliet, Tobias A J Nijman, Ewoud Schuit, Karst Y Heida, Brent C Opmeer, Marjolein Kok, Wilfried Gyselaers, Martina M Porath, Mallory Woiski, Caroline J Bax, Kitty W M Bloemenkamp, Hubertina C J Scheepers, Yves Jacquemyn, Erik van Beek, Johannes J Duvekot, Maureen T M Franssen, Dimitri N Papatsonis, Joke H Kok, Joris A M van der Post, Arie Franx, Ben W Mol, Martijn A Oudijk

Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study

Simon Cauchemez, Marianne Besnard, Priscillia Bompard, Timothée Dub, Prisca Guillemette-Artur, Dominique Eyrolle-Guignot, Henrik Salje, Maria D Van Kerkhove, Véronique Abadie, Catherine Garel, Arnaud Fontanet, Henri-Pierre Mallet


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Costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Priorities, 3rd edition

Hellen Gelband, Rengaswamy Sankaranarayanan, Cindy L Gauvreau, Susan Horton, Benjamin O Anderson, Freddie Bray, James Cleary, Anna J Dare, Lynette Denny, Mary K Gospodarowicz, Sumit Gupta, Scott C Howard, David A Jaffray, Felicia Knaul, Carol Levin, Linda Rabeneck, Preetha Rajaraman, Terrence Sullivan, Edward L Trimble, Prabhat Jha, Disease Control Priorities-3 Cancer Author Group

Health Policy

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The World report on ageing and health: a policy framework for healthy ageing

John R Beard, Alana Officer, Islene Araujo de Carvalho, Ritu Sadana, Anne Margriet Pot, Jean-Pierre Michel, Peter Lloyd-Sherlock, JoAnne E Epping-Jordan, G M E E (Geeske) Peeters, Wahyu Retno Mahanani, Jotheeswaran Amuthavalli Thiyagarajan, Somnath Chatterji

Protecting human security: proposals for the G7 Ise-Shima Summit in Japan

Japan Global Health Working Group

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La Enciclopedia de Cuba

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DSCN0342En la presentación de la Enciclopedia de Cuba, de la que la Prof. DraC. Consuelo Macías Abraham es autora, durante el acto efectuado en la Sociedad Económica de Amigos del País.

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