Tag Archive 'tiazidas'

Viernes 15 / marzo / 2013

Hypertension: Should thiazides be used for hypertension in obese patients?

Filed under: factores de riesgo — Mario Hernández Cueto — marzo 15th, 2013 — 10:22

Hypertension: Should thiazides be used for hypertension in obese patients?

Riesgo cardiovascularPor: Susan J. Allison.  Nature Reviews Cardiology 10, 62 (February 2013).

Previous studies of hypertensive patients at high risk of cardiovascular events have reported paradoxically higher event rates in normal-weight patients than in obese individuals. A subanalysis of ACCOMPLISH trial data suggests that this paradox might reflect the differential effects of antihypertensive treatment types, rather than the effect of body size, per se.
The ACCOMPLISH trial aimed to compare the effects of benazepril plus amlodipine versus benazepril plus a thiazide diuretic (hydrochlorothiazide) in hypertensive patients at high risk of cardiovascular events. As a prespecified subanalysis, Michael Weber and colleagues have now assessed patient outcomes on the basis of BMI, by categorizing participants as either obese (BMI ≥30 kg/m2; n = 5,709), overweight (BMI ≥25 to <30 kg/m2; n = 4,157) or normal weight (BMI <25 kg/m2; n = 1,616). [Actualizado: 15 de marzo 2013].

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Jueves 17 / enero / 2013

The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio

Filed under: comentario — Mario Hernández Cueto — enero 17th, 2013 — 7:33

Esta sección mostrará algunos trabajos que puedan ser útiles a nuestros facultativos por su interés práctico o teórico.

The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio

ComentandoPor: Susan J. Hood, RGN; Kevin P. Taylor, MSc; Michael J. Ashby, BSc; Morris J. Brown y FMedSci.  Circulation. 2007; 116: 268-275.

There is continuing variation in diagnosis and estimated prevalence of primary hyperaldosteronism. The higher estimates encourage search for adrenal adenomas in patients with elevated ratios of plasma aldosterone to renin. However, it is more likely that patients with normal plasma K+ and aldosterone belong to the polygenic spectrum of low-renin hypertension rather than have the same monogenic syndrome as classic Conn’s. [actualizada: 17 de enero 2013]

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