Tag Archive 'emergencia hipertensiva'

Martes 11 / junio / 2013

Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLUE trial

Filed under: investigaciones — Mario Hernández Cueto — junio 11th, 2013 — 9:43

Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLUE trial

InvestigacionesPor: Chad M Cannon, Phillip Levy, Brigitte M Baumann, Pierre Borczuk, Abhinav Chandra, David M Cline, Deborah B Diercks, Brian Hiestand, Amy Hsu, Preeti Jois, Brian Kaminski, Richard M Nowak, Jon W Schrock, Joseph Varon y W Frank Peacock.    BMJ Open 2013;3:e002338 doi.

To compare the efficacy of Food and Drug Administration recommended dosing of nicardipine versus labetalol for the management of hypertensive patients with signs and/or symptoms (S/S) suggestive of end-organ damage (EOD). Design Secondary analysis of the multicentre prospective, randomised CLUE trial. In the setting of hypertension with suspected EOD, patients treated with nicardipine are more likely to reach prespecified SBP targets within 30 min than patients receiving labetalol. [Actualizado: 11 de junio de 2013].

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Martes 28 / mayo / 2013

Hypertensive emergencies are associated with elevated markers of inflammation, coagulation, platelet activation and fibrinolysis

Filed under: Editorial — Mario Hernández Cueto — mayo 28th, 2013 — 13:37

Editorial. Estudios importantes sobre hipertension arterial de Cuba y el mundo

Hypertensive emergencies are associated with elevated markers of inflammation, coagulation, platelet activation and fibrinolysis

EditorialPor: U Derhaschnig, C Testori, E Riedmueller, S Aschauer, M Wolzt y B Jilma.   Journal of Human Hypertension (2013) 27, 368–373.

Hypertensive crises are frequently observed medical events. They comprise critical elevation of blood pressure (BP) complicated by target organ dysfunction, defined as hypertensive emergency (HE) or without target organ deterioration, that is, hypertensive urgency (HU). Data from in vitro and animal experiments suggest that progressive endothelial damage with subsequent activation of coagulation and inflammation have a key role in hypertensive crisis. However, clinical investigations are scarce. We hypothesized that hypertensive emergencies are associated with enhanced inflammation, endothelial- and coagulation activation. Thus, we enrolled 60 patients admitted to an emergency department in a prospective, cross-sectional study.  [Actualizado: 28 de mayo 2013]

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Jueves 25 / abril / 2013

Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLUE trial

Filed under: Revisiones — Mario Hernández Cueto — abril 25th, 2013 — 11:45

Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLUE trial

bmj-open-2013Por: Chad M Cannon, Phillip Levy, Brigitte M Baumann, Pierre Borczuk, Abhinav Chandra, David M Cline, Deborah B Diercks, Brian Hiestand, Amy Hsu, Preeti Jois, Brian Kaminski, Richard M Nowak, Jon W Schrock, Joseph Varon y W Frank Peacock.   BMJ Open 2013;3:e002338 doi:10.1136/bmjopen-2012-002338.

Systemic hypertension is a common medical condition affecting over 75 million Americans and over 1 billion people worldwide. Currently, it is estimated that 1–2% of patients with hypertension will have a hypertensive emergency during their life.  Defined by the presence of acute end-organ dysfunction, hypertensive emergencies are high risk, associated with in-hospital and 30-day death rates of 2–3% and 11%, respectively, and a 90-day re-admission rate of nearly 40%. Rapid recognition, evaluation and treatment of hypertensive emergencies are necessary to prevent permanent or progressive end-organ damage (EOD). [Actualizado: 25 de abril 2013]

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