Tag Archive 'eficacia'

Jueves 25 / abril / 2013

Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension

Filed under: comentario — Mario Hernández Cueto — abril 25th, 2013 — 11:13

Esta sección mostrará algunos trabajos que puedan ser útiles a nuestros facultativos por su interés práctico o teórico.

Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension

comentandoPor: Scott S Billecke y Pamela A Marcovitz.  DOVE MEDICAL March 2013, Volume 2013:9 Pages 95 – 104.

The use of multiple drug regimens is increasingly recognized as a tacit requirement for the management of hypertension, a necessity fueled in part by rising rates of metabolic syndrome and diabetes. By targeting complementary pathways, combinations of antihypertensive drugs can be applied to provide effective blood pressure control while minimizing side effects and reducing exposure to high doses of individual medications. In addition, combination therapies, including angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs), have the added benefit of reducing cardiovascular mortality and morbidity over other dual therapies while providing equivalent blood pressure control. It is possible that angiotensin receptor blockers (ARBs), which unlike ACE inhibitors are minimally affected by upregulation of alternative pathways for angiotensin II accumulation following long-term treatment, would also provide such outcome benefits.  [Actualizado: 25 de abril 2013].

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Viernes 21 / diciembre / 2012

Combined effect of angiotensin II receptor blocker and either a calcium channel blocker or diuretic on day-by-day variability of home blood pressure: the Japan Combined Treatment With Olmesartan and a Calcium-Channel Blocker Versus Olmesartan and Diuretics Randomized Efficacy Study.

Filed under: Revisiones — Mario Hernández Cueto — diciembre 21st, 2012 — 12:09

Combined effect of angiotensin II receptor blocker and either a calcium channel blocker or diuretic on day-by-day variability of home blood pressure: the Japan Combined Treatment With Olmesartan and a Calcium-Channel Blocker Versus Olmesartan and Diuretics Randomized Efficacy Study.

cochranePor: Matsui Y, O’Rourke MF, Hoshide S, Ishikawa J, Shimada K y Kario K. Hypertension, 2012 Jun. Vol. 59, Issue: 6: 1132-8. Cochrane BVS.

Day-by-day home blood pressure (BP) variability (BPV) was reported to be associated with increased cardiovascular risk. We aimed to test the hypothesis that the angiotensin II receptor blocker/calcium-channel blocker combination decreases day-by-day BPV more than the angiotensin II receptor blocker/diuretic combination does and investigated the mechanism underlying the former reduction. [publicada: 21 de diciembre 2012]

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Lunes 3 / diciembre / 2012

Antihypertensive Efficacy of Hydrochlorothiazide vs Chlorthalidone Combined with Azilsartan Medoxomil.

Filed under: Revisiones — Mario Hernández Cueto — diciembre 3rd, 2012 — 10:52

Antihypertensive Efficacy of Hydrochlorothiazide vs Chlorthalidone Combined with Azilsartan Medoxomil.

Evidence updatesPor: Bakris GL, Sica D, White WB, et al.  Am J Med. 2012 Dec;125(12):1229.e1-1229.

Chlorthalidone combined with azilsartan medoxomil provides better blood pressure reduction and a higher likelihood of achieving blood pressure control than hydrochlorothiazide combined with azilsartan medoxomil. This benefit occurred without a difference in safety measurements. [publicada: 3 de diciembre de 2012.]

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