Archive for the 'Revisiones'

Jueves 10 / abril / 2014

The evidence for treating hypertension in older people with dementia: a systematic review

Filed under: Revisiones — Mario Hernández Cueto — abril 10th, 2014 — 8:04

The evidence for treating hypertension in older people with dementia: a systematic review

Revisiones sistemáticasPor: L C Beishon, J K Harrison, R H Harwood, T G Robinson, J R F Gladman y S P Conroy.  Journal of Human Hypertension (2014) 28, 283–287.

Hypertension and dementia commonly co-exist in older people, yet guidance is lacking on how to manage these co-existing conditions. The aim of this systematic review was to assess the evidence for the treatment of hypertension in older people with dementia. Medline, EMBASE, Cochrane Library and the national research register archives were searched. Inclusion criteria were: randomised controlled trial of hypertension treatment, included participants aged 65+ years, participants had a diagnosis of dementia (global cognitive decline for at least 6 months affecting daily function), and the study assessed cognitive outcomes using validated tools.

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Lunes 10 / marzo / 2014

CYP3A5 polymorphism, amlodipine and hypertension

Filed under: Revisiones — Mario Hernández Cueto — marzo 10th, 2014 — 10:11

CYP3A5 polymorphism, amlodipine and hypertension

Revisiones sistematicasPor: Y-P Zhang,  X-C Zuo, Z-J Huang, J-J Cai, J Wen, D D Duan y  H Yuan.   Journal of Human Hypertension (2014) 28, 145–149.

As a major cardiovascular risk factor for stroke, coronary artery disease, heart failure and end-stage renal disease, hypertension affects approximately one billion people and causes large economic burden worldwide. Cytochrome P450 3A5 (CYP3A5), belonging to the CYP3A subfamily, has been implicated in the regulation of blood pressure and may serve as a potential risk factor for the development of hypertension. Increased CYP3A5 activity could cause sodium and water retention by affecting the metabolism of cortisol in the kidneys. Furthermore, polymorphic CYP3A5 genotypes have been shown to cause differences in blood pressure response to antihypertensive drugs.

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Martes 25 / febrero / 2014

Nocturnal blood pressure and cardiovascular disease: a review of recent advances

Filed under: Revisiones — Mario Hernández Cueto — febrero 25th, 2014 — 11:33

Nocturnal blood pressure and cardiovascular disease: a review of recent advances

Revisiones-sistematicasPor: Yuichiro Yano y Kazuomi Kario. Hypertension Research (2012) 35, 695–701.

The accurate measurement, prediction and treatment of high blood pressure (BP) are essential issues in the management of hypertension. Ambulatory blood pressure monitoring (ABPM) has been shown to be superior
to clinic BP measurements as ABPM can provide the following important information: (i) the mean BP levels, (ii) the diurnal variation in BP and (iii) the short-term BP variability. Among these parameters, there is increasing evidence that the mean nocturnal BP level is the most sensitive predictor of cardiovascular morbidity and mortality. Furthermore, several studies have shown that less nocturnal BP dipping, defined as less nocturnal BP decline relative to daytime BP, or a high night–day BP ratio was associated with poor prognosis irrespective of the 24-hour BP levels.

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Miércoles 12 / febrero / 2014

Effect of Dietary Pulses on Blood Pressure: A Systematic Review and Meta-analysis of Controlled Feeding Trials

Filed under: Revisiones — Mario Hernández Cueto — febrero 12th, 2014 — 10:15

Effect of Dietary Pulses on Blood Pressure: A Systematic Review and Meta-analysis of Controlled Feeding Trials

Revisiones sistematicasPor: Viranda H. Jayalath, Russell J. de Souza, John L. Sievenpiper, Vanessa Ha, Laura Chiavaroli, Arash Mirrahimi, Marco Di Buono, Adam M. Bernstein, Lawrence A. Leiter, Penny M. Kris-Etherton, Vladimir Vuksan, Joseph Beyene, Cyril W.C. Kendall y David J.A. Jenkins.   Am J Hypertens (2014) 27 (1): 56-64.

Current guidelines recommend diet and lifestyle modifications for primary prevention and treatment of hypertension, but do not encourage dietary pulses specifically for lowering blood pressure (BP). To quantify the
effect of dietary pulse interventions on BP and provide evidence for their inclusion in dietary guidelines, a systematic review and meta-analysis of controlled feeding trials was conducted.  Dietary pulses significantly
lowered BP in people with and without hypertension. Higher-quality large-scale trials are needed to support these findings.

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