Archive for the 'investigaciones'

Miércoles 6 / agosto / 2014

Are There Any New Pharmacologic Therapies on the Horizon to Better Treat Hypertension?

Filed under: investigaciones — Mario Hernández Cueto — agosto 6th, 2014 — 15:43

Are There Any New Pharmacologic Therapies on the Horizon to Better Treat Hypertension?

InvestigacionesPor: Gabriel B. Habib, Sr, MS, MD, FACC, FCCP, FAHA, Sukhdeep S. Basra, MD, MPH.  J CARDIOVASC PHARMACOL THER May 1, 2014( 107).

Hypertension is the most important cardiovascular risk factor. We have witnessed a significant improvement in hypertension treatment and control and an impressive growth in the pharmacologic options available to clinicians and hypertension specialists. With up to a third of patients with hypertension not at the recommended goal blood pressures, it is critically important to develop novel therapeutic approaches to better treat hypertension.

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Miércoles 6 / agosto / 2014

Current and Newer Agents for Hypertensive Emergencies

Filed under: investigaciones — Mario Hernández Cueto — agosto 6th, 2014 — 15:29

Current and Newer Agents for Hypertensive Emergencies

InvestigacionesPor: Alan Padilla Ramos & Joseph Varon.  Curr Hypertens Rep (2014) 16:450 DOI 10.1007

Hypertension is an increasingly prevalent chronic illness. The condition may present as a hypertensive crisis, and this entity may be further categorized as either hypertensive emergency or urgency. As the presentation is quite variable and is dependent upon the specific end-organ injury, a thorough history and examination are necessary. Once the underlying pathology is known, a target blood pressure can be determined and a specific therapeutic agent selected.   The choice of most appropriate agent must take into consideration coexisting morbidities, desired rate of blood pressure decline, monitoring capabilities of the environment, and experience of the clinician. In hypertensive emergencies, the therapeutic goal is to protect remaining end-organ function, reduce the risk of complications, and thereby improve patient outcomes.

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Miércoles 11 / junio / 2014

Ethnic differences in genetic predisposition to hypertension

Filed under: investigaciones — Mario Hernández Cueto — junio 11th, 2014 — 10:09

Ethnic differences in genetic predisposition to  hypertension

InvestigacionesPor: Norihiro Kato.  Hypertension Research (2012) 35, 574–581.

Genetic, environmental and demographic factors and their interaction determine an individual’s risk for hypertension. Despite considerable efforts to investigate the genetic basis of hypertension, or elevated blood pressure (BP) levels, the inherently complex nature hampered progress in the elucidation of the genes involved and yielded little success until 2009 when two consortia-based meta-analyses of genome-wide association (GWA) studies involving 30?000–40?000 samples in the discovery stage identified a total of 13 independent loci significantly associated with BP in populations of European descent.

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Martes 27 / mayo / 2014

Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: A systematic review

Filed under: investigaciones — Mario Hernández Cueto — mayo 27th, 2014 — 12:42

Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: A systematic review

InvestigacionesPor: Shunping Gui1, Jin Jia1,  Xiaoyu Niu, Yi Bai,  Heng Zou,  Juelin Deng y  Rong Zhou.  Journal of Renin-Angiotensin-Aldosterone System, March 2014 vol.

Hypertensive disorder of pregnancy is one of the most common perinatal diseases,1 accounting for about 10%-15% of pregnancies.  It can be defined as the onset of hypertension after the 20th week of pregnancy, with systolic and diastolic pressure higher than 140 and 90 mm Hg on at least two different occasions.4 However, the pathogenesis of preeclampsia remains elusive, and prevention through routine supplementations with calcium, magnesium, omega-3 fatty acids, or antioxidant vitamins are ineffective.5??–8 To date, it is certain that pregnancy has been reported to be a state of relative arginine deficiency. Arginine is one kind of essential amino acid, physiologically active in L-form, which is synthesized by endothelial cells and excreted with urine in vivo.  Arginine has been well recognized as a drug to treat variable diseases and symptoms, as well as a dietary tonic.

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