Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a com-plex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain  skin inflammation. Anti-tumour necrosis factor (anti-TNF)-α agents have been approved for therapeutic use across a range of inflammatory disorders including psoriasis, but the anti-inflammatory mechanisms of anti-TNF-α in lesional psoriatic skin are not fully understood. We investigated early events in skin from psoriasis patients after treatment with anti-TNF-α antibodies by use of bioinformatic s tools.