Tag Archive 'Metaanálisis'

Lunes 26 / marzo / 2012

A systematic review and meta-analysis of complications associated with acellular dermal matrix-assisted breast reconstruction.

Filed under: Artículos recomendados antiguos — Dr. Pável Reyes Rodríguez — marzo 26th, 2012 — 3:28 PM

A systematic review and meta-analysis of complications associated with acellular dermal matrix-assisted breast reconstruction
Ho G, Nguyen TJ, Shahabi A, Hwang BH, Chan LS, Wong AK.
Ann Plast Surg. 2012 Apr;68(4):346-56.

ovidwebcgi4Múltiples estudios que se han publicado sobre el uso de la Matriz Dérmica Acelular (MDA) en la reconstrucción mamaria han mostrado resultados dispares. El propósito de este estudio fue conducirnos a una revisión sistemática y meta-análisis para determinar el estimado de riesgo asociado a la utilización de la MDA en la reconstrucción mamaria.

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Viernes 16 / marzo / 2012

Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature.

Filed under: Temas de meses anteriores — Dr. Pável Reyes Rodríguez — marzo 16th, 2012 — 1:53 PM

Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature
Leventhal D, Furr M, Reiter D.
Arch Facial Plast Surg. 2006 Nov-Dec;8(6):362-8.

archives-facial-of-plastic-surgeryManagement of hypertrophic scars and keloids has advanced from crude, invasive methods such as gross excision and radiation to intralesional or topical agents that act on a cellular level. There is no universally accepted treatment regimen and no evidence-based literature to guide management. Our objectives are to present a list of available treatment regimens, their proposed mechanisms of action, and supporting evidence and to perform a meta-analysis of clinical trials to identify treatments with a better-than-even likelihood of improvement. We conducted a PubMed search through October 2005, identifying clinical studies of various treatments for hypertrophic scars and keloids. We graded the quality of each study, delineated the results into favorable vs nonfavorable, and calculated the statistical significance of the findings. The meta-analysis of 70 treatment series for various clinical measures showed a 70% chance of improvement with treatment; however, the mean amount of improvement to be expected was around 60%. There was no statistically significant difference between treatments. Most treatments for keloidal and hypertrophic scarring offer minimal likelihood of improvement. The magnitude of likely permanent improvement in any sign or symptom may be clinically meaningful but far short of cure. Novel therapies deserve further investigation but remain without proven benefit to date.

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