Eficacia de un apósito autoadhesivo de poliuretano para prevenir la formación de cicatrices hipertróficas
Bisbal, J.
Cir. plást. iberolatinoam. [online]. 2011, vol.37, n.4, pp. 341-347.

Valoramos la eficacia de un apósito autoadhesivo para prevenir las cicatrices hipertróficas sobre un grupo de pacientes sometidas a cirugía de reducción mamaria. Tras la curación de las heridas, aplicamos en todas las pacientes un protocolo preventivo mediante compresión y apósito adhesivo.

Tags: Apósito de poliuretano, Cicatrices hipertróficas, Cicatrización patológica, Prevención

Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature
Leventhal D, Furr M, Reiter D.
Arch Facial Plast Surg. 2006 Nov-Dec;8(6):362-8.

Management of hypertrophic scars and keloids has advanced from crude, invasive methods such as gross excision and radiation to intralesional or topical agents that act on a cellular level. There is no universally accepted treatment regimen and no evidence-based literature to guide management. Our objectives are to present a list of available treatment regimens, their proposed mechanisms of action, and supporting evidence and to perform a meta-analysis of clinical trials to identify treatments with a better-than-even likelihood of improvement. We conducted a PubMed search through October 2005, identifying clinical studies of various treatments for hypertrophic scars and keloids. We graded the quality of each study, delineated the results into favorable vs nonfavorable, and calculated the statistical significance of the findings. The meta-analysis of 70 treatment series for various clinical measures showed a 70% chance of improvement with treatment; however, the mean amount of improvement to be expected was around 60%. There was no statistically significant difference between treatments. Most treatments for keloidal and hypertrophic scarring offer minimal likelihood of improvement. The magnitude of likely permanent improvement in any sign or symptom may be clinically meaningful but far short of cure. Novel therapies deserve further investigation but remain without proven benefit to date.

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Tags: Cicatrices hipertróficas, Cicatrización patológica, Metaanálisis, Queloides, Revisión, Tratamiento

Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies
Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG.
Mol Med. 2011 Jan-Feb;17(1-2):113-25.

Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient’s quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

Tags: Cicatrices hipertróficas, Cicatrización patológica, Queloides, Tratamiento