In vitro optimisation of topical negativepressure regimens for angiogenesis into synthetic dermal replacements

Posted at — Dr. Pável Reyes Rodríguez — mayo 22nd, 2012 — 11:07 AM under Temas de meses anteriores

In vitro optimisation of topical negativepressure regimens for angiogenesis into synthetic dermal replacements
Potter M, Banwell P, Baldwin C, Clayton E, Irvine L, Linge C, Grobbelaar A, Sanders R, Dye J.
Burns. 2008 March;34(2):164-174.

burnsThe use of synthetic dermal replacements (SDRs) in the treatment of large wounds, which have associated morbidity and mortality, has attracted great interest. However, because of poor outcome, SDRs have limited use. The addition of topical negativepressure (TNP) has increased their success, but little research has focused on the underlying mechanisms. This paper studies the in vitro effects of TNP on commonly used SDRs to identify the most effective TNP regimen and optimum SDR for encouraging endothelial cell ingress.

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