Molecular dissection of abnormal wound healing processes resulting in keloid disease.

Posted at — Dr. Pável Reyes Rodríguez — marzo 16th, 2012 — 2:10 PM under Temas de meses anteriores

Molecular dissection of abnormal wound healing processes resulting in keloid disease
Shih B, Garside E, McGrouther DA, Bayat A.
Wound Repair Regen. 2010 Mar-Apr;18(2):139-53.

cover3Keloids are locally aggressive scars that typically invade into healthy surrounding skin and cause both physical and psychosocial distress to the patient. These pathological scars occur following minimal skin trauma after a variety of causes including burns and trauma. Although the pathogenesis of keloid disease is not well understood, it is considered to be the end product of an abnormal healing process. The aim of this review was to investigate the molecular and cellular pathobiology of keloid disease in relation to the normal wound healing process. This review presents a detailed account of individual phases of the healing process and how they may potentially be implicated in aberrant raised scar formation, which may help in clarifying the mechanisms involved in keloid disease pathogenesis.

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